Beilstein J. Org. Chem.2021,17, 1181–1312, doi:10.3762/bjoc.17.90
investment to maintain and operate (requirements for large volumes of solvent during work-ups and cleaning of reactors between processes). Alternatively, in the continuous-flow approach, a fully automatedreactionsystem can be assembled, in which, transformations occur within reactors with a continuous
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Graphical Abstract
Figure 1:
Representative shares of the global F&F market (2018) segmented on their applications [1].
Beilstein J. Org. Chem.2017,13, 150–163, doi:10.3762/bjoc.13.18
experimental efficiency. The self-optimisation approach required the least number of experiments to reach the specified objectives of cost and product yield, whereas the MBDoE approach enabled a rapid generation of a process model.
Keywords: automatedreactionsystem; C–H activation; design of experiments
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Graphical Abstract
Figure 1:
A framework of closed-loop or self-optimisation combining smart DoE algorithms, process analytics, ...